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pentobarbital will decrease the extent or influence of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or effect of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Lessened AUC of tramadol as well as Energetic metabolite (O-desmethyltramadol) when c